Ontology highlight
ABSTRACT:
SUBMITTER: Grosserichter-Wagener C
PROVIDER: S-EPMC7190975 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Grosserichter-Wagener Christina C Franco-Gallego Alexander A Ahmadi Fatemeh F Moncada-Vélez Marcela M Dalm Virgil Ash VA Rojas Jessica Lineth JL Orrego Julio César JC Correa Vargas Natalia N Hammarström Lennart L Schreurs Marco Wj MW Dik Willem A WA van Hagen P Martin PM Boon Louis L van Dongen Jacques Jm JJ van der Burg Mirjam M Pan-Hammarström Qiang Q Franco José L JL van Zelm Menno C MC
Clinical & translational immunology 20200429 5
<h4>Objective</h4>Selective IgA deficiency (sIgAD) is the most common primary immunodeficiency in Western countries. Patients can suffer from recurrent infections and autoimmune diseases because of a largely unknown aetiology. To increase insights into the pathophysiology of the disease, we studied memory B and T cells and cytokine concentrations in peripheral blood.<h4>Methods</h4>We analysed 30 sIgAD patients (12 children, 18 adults) through detailed phenotyping of peripheral B-cell, CD8<sup>+ ...[more]