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N,O-Nucleoside Analogues: Metabolic and Apoptotic Activity.

ABSTRACT: Two new families of N,O-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear fragmentation was evidenced in treated cells.

SUBMITTER: Marraffa A

PROVIDER: S-EPMC7197084 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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<i>N,O</i>-Nucleoside Analogues: Metabolic and Apoptotic Activity.

Marraffa Andrea A Presenti Piero P Macchi Beatrice B Marino-Merlo Francesca F Mella Mariella M Quadrelli Paolo P

ChemistryOpen 20200324 5

Two new families of <i>N,O</i>-nucleoside analogues containing the anthracene moiety introduced through the nitrosocarbonyl ene reaction with allylic alcohols were prepared. The core structure is an isoxazolidine heterocycle that introduces either atom either a phenyl ring or dimethyl moiety at the C3 carbon. Different heterobases were inserted at the position 5 of the heterocyclic ring. One of the synthesized compounds demonstrated a good capacity to induce cell death and an appreciable nuclear ...[more]

PMID: 32373422

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