Ontology highlight
ABSTRACT:
SUBMITTER: Pallikkuth S
PROVIDER: S-EPMC7213985 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Pallikkuth Suresh S Chaudhury Sidhartha S Lu Pinyi P Pan Li L Jongert Erik E Wille-Reece Ulrike U Pahwa Savita S
eLife 20200429
Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively). To investigate the underlying immunologic mechanism, we analyzed the B and T peripheral follicular helper cell (pTfh) responses. Here, we show that protection in both study arms was associated with early induction of functional IL-21-se ...[more]