The Mechanism of ?2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.
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ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7240133 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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The Mechanism of β2m Molecule-Induced Changes in the Peptide Presentation Profile in a Bony Fish.
Li Zibin Z Zhang Nianzhi N Ma Lizhen L Zhang Lijie L Meng Geng G Xia Chun C
iScience 20200430 5
Contemporary antigen presentation knowledge is based on the existence of a single β2m locus, and a classical MHC class I forms a complex with a peptide (i.e., pMHC-I) to trigger CTL immunity. However, two β2m loci have been found in diploid bony fish; the function of the two β2m molecules is unclear. Here, we determined the variant peptide profiles originating from different products of the β2m loci binding to the same MHC-I molecule and further solved the crystal structures of the two pMHC-I mo ...[more]
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