Ontology highlight
ABSTRACT:
SUBMITTER: Wu H
PROVIDER: S-EPMC7243482 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20170401 15
Chiral vinylogous β-amino acids (VBAA) were synthesized using enantioselective Mannich reactions of aldehydes with in situ generated N-carbamoyl imines followed by a Horner-Wadsworth-Emmons reaction. The efficiency with which these units could be incorporated into oligomers with different moieties on the C- and N-terminal sides was established, as was the feasibility of sequencing oligomers containing VBAAs by tandem mass spectrometry. The data show that VBAAs will be useful building blocks for ...[more]