Ontology highlight
ABSTRACT:
SUBMITTER: Gomide MS
PROVIDER: S-EPMC7244727 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Communications biology 20200522 1
Recently, new serine integrases have been identified, increasing the possibility of scaling up genomic modulation tools. Here, we describe the use of unidirectional genetic switches to evaluate the functionality of six serine integrases in different eukaryotic systems: the HEK 293T cell lineage, bovine fibroblasts and plant protoplasts. Moreover, integrase activity was also tested in human cell types of therapeutic interest: peripheral blood mononuclear cells (PBMCs), neural stem cells (NSCs) an ...[more]