Ontology highlight
ABSTRACT:
SUBMITTER: Leal LG
PROVIDER: S-EPMC7284038 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Leal Luis G LG Hoggart Clive C Jarvelin Marjo-Riitta MR Herzig Karl-Heinz KH Sternberg Michael J E MJE David Alessia A
Molecular genetics & genomic medicine 20200419 6
<h4>Background</h4>Severe hypercholesterolemia (HC, LDL-C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL-C.<h4>Methods</h4>Summary statistics from the Global Lipid Genome Consortium and genotype data from two large populations were used.<h4>Results</h4>A 36-SNP PRS was generated using data for 2,197 white Americans. In a replication cohort of 4,787 Finns, the PRS was strongly associated with the LDL-C trait and explain ...[more]