Ontology highlight
ABSTRACT:
SUBMITTER: Nassar ZD
PROVIDER: S-EPMC7386908 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nassar Zeyad D ZD Mah Chui Yan CY Dehairs Jonas J Burvenich Ingrid Jg IJ Irani Swati S Centenera Margaret M MM Helm Madison M Shrestha Raj K RK Moldovan Max M Don Anthony S AS Holst Jeff J Scott Andrew M AM Horvath Lisa G LG Lynn David J DJ Selth Luke A LA Hoy Andrew J AJ Swinnen Johannes V JV Butler Lisa M LM
eLife 20200720
Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we demonstrate therapeutic efficacy of targeting FAO in clinical prostate tumors cultured ex vivo, and identify <i>DECR1,</i> encoding the rate-limiting enzyme for oxidation of polyunsaturated fatty acids (PUFAs), as robustly overexpressed in PCa tissues and associated with shorter relapse-free survival. <i>DECR1</i> is a negatively-regulated androgen ...[more]