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Anti-Inflammatory Effects of Fermented Bark of Acanthopanax sessiliflorus and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells.

ABSTRACT: The fermentation was carried out on the bark of Acanthopanax sessiliflorus (AS). Acanthopanax species have been used in traditional medicine as tonics, sedatives, and antispasmodics. An activity-guided isolation of the fermented bark of A. sessiliflorus (FAS) yielded several phytochemicals: acanthoside D (1), acanthoside B (2), daucosterol (3), protocatechuic acid (4), chlorogenic acid methyl ester (5), ciwujiatone (6), syringaresinol (7), farnesol (8), 3,4-dicaffeoylquinic acid (9), and falcarindiol (10). HPLC analysis showed that content of lignan glycoside (1) was decreased and 4 and 7 were increased after fermentation. Anti-inflammatory activities on FAS showed the decrease of nitric oxide (NO) production, and inhibitory activities of iNOS and COX-2, proinflammatory cytokines (IL-6 and tumor necrosis factor-?), and collagenase. The aglycone, syringaresinol (7), which was increased through fermentation showed enhanced activity than 1. Thus, FAS may have the potential to treat inflammatory disorders, such as arthritis.

SUBMITTER: Kim MJ 

PROVIDER: S-EPMC7391118 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Anti-Inflammatory Effects of Fermented Bark of <i>Acanthopanax sessiliflorus</i> and Its Isolated Compounds on Lipopolysaccharide-Treated RAW 264.7 Macrophage Cells.

Kim Min Ji MJ   Wang Hye Soo HS   Lee Min Won MW  

Evidence-based complementary and alternative medicine : eCAM 20200721

The fermentation was carried out on the bark of <i>Acanthopanax sessiliflorus</i> (AS). <i>Acanthopanax</i> species have been used in traditional medicine as tonics, sedatives, and antispasmodics. An activity-guided isolation of the fermented bark of <i>A. sessiliflorus</i> (FAS) yielded several phytochemicals: acanthoside D (<b>1</b>), acanthoside B (<b>2</b>), daucosterol (<b>3</b>), protocatechuic acid (<b>4</b>), chlorogenic acid methyl ester (<b>5</b>), ciwujiatone (<b>6</b>), syringaresino  ...[more]

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