Unknown

Dataset Information

0

2'-Fluoro-2'-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705.


ABSTRACT: Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2'-fluoro-2'-deoxycytidine (2'-FdC) has been reported to have broad antiviral activity. Here, we report that 2'-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation of cytidine triphosphate. The combination of 2'-FdC with mycophenolic acid, ribavirin or favipiravir (T705) exerts synergistic antiviral effects. These results indicate that 2'-FdC is a potential candidate for antiviral drug development against norovirus infection.

SUBMITTER: Yu P 

PROVIDER: S-EPMC7414258 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6201076 | biostudies-literature
| S-EPMC6409565 | biostudies-literature
| S-EPMC4519282 | biostudies-literature
| S-EPMC5602043 | biostudies-literature
| S-EPMC6046605 | biostudies-literature
| S-EPMC4442456 | biostudies-literature
2015-04-19 | E-GEOD-61562 | biostudies-arrayexpress
| S-EPMC5801037 | biostudies-literature
| S-EPMC6356845 | biostudies-other
2015-04-19 | GSE61562 | GEO