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STAT3-mediated CD133 upregulation promotes hepatocellular carcinoma

ABSTRACT: We identified a novel mechanism by which IL-6/STAT3 signaling up-regulates CD133 expression and promotes HCC progression. STAT3 activation upregulates the expression of CD133 during liver carcinogenesis. Targeting STAT3-mediated CD133 overexpression may represent a promising therapeutic strategy for HCC patients via eradicating the liver tumor microenviornment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE60194 | GEO | 2014/08/08

SECONDARY ACCESSION(S): PRJNA257733

REPOSITORIES: GEO

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STAT3-mediated CD133 upregulation promotes hepatocellular carcinoma

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