Ontology highlight
ABSTRACT:
SUBMITTER: Vykoukal J
PROVIDER: S-EPMC7453025 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Vykoukal Jody J Fahrmann Johannes F JF Gregg Justin R JR Tang Zhe Z Basourakos Spyridon S Irajizad Ehsan E Park Sanghee S Yang Guang G Creighton Chad J CJ Fleury Alia A Mayo Jeffrey J Paulucci-Holthauzen Adriana A Dennison Jennifer B JB Murage Eunice E Peterson Christine B CB Davis John W JW Kim Jeri J Hanash Samir S Thompson Timothy C TC
Nature communications 20200827 1
Plasma and tumor caveolin-1 (Cav-1) are linked with disease progression in prostate cancer. Here we report that metabolomic profiling of longitudinal plasmas from a prospective cohort of 491 active surveillance (AS) participants indicates prominent elevations in plasma sphingolipids in AS progressors that, together with plasma Cav-1, yield a prognostic signature for disease progression. Mechanistic studies of the underlying tumor supportive onco-metabolism reveal coordinated activities through w ...[more]