Role for ovarian hormones in purinoceptor-dependent natriuresis.

ABSTRACT:

Background

Premenopausal women have a lower risk of hypertension compared to age-matched men and postmenopausal women. P2Y₂ and P2Y₄ purinoceptor can be considered potential contributors to hypertension due to their emerging roles in regulating renal tubular Na⁺ transport. Activation of these receptors inhibits epithelial Na⁺ channel activity (ENaC) via a phospholipase C (PLC)-dependent pathway resulting in natriuresis. We recently reported that activation of P2Y₂ and P2Y₄ receptors in the renal medulla by UTP promotes natriuresis in male and ovariectomized (OVX) rats, but not in ovary-intact females. This led us to hypothesize that ovary-intact females have greater basal renal medullary activity of P2 (P2Y₂

SUBMITTER: Gohar EY 

PROVIDER: S-EPMC7490965 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature