Ontology highlight
ABSTRACT:
SUBMITTER: Liu Z
PROVIDER: S-EPMC7493893 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Liu Zhi Z Zhang Haohao H Hu Yiming Y Liu Dandan D Li Lingling L Li Cuifeng C Wang Qi Q Huo Junhaohui J Liu Hanshao H Xie Ningxia N Huang Xingxu X Liu Yongzhong Y Chen Charlie Degui CD Shi Yufang Y Shi Yufang Y Zhang Xiaoren X
Cell death and differentiation 20200428 10
Medullary thymic epithelial cells (mTECs) play a central role in the establishment of T cell central immunological tolerance by promiscuously expressing tissue-restricted antigens (TRAs) and presenting them to developing T cells, leading to deletion of T cells responding to self-antigens. However, molecular mechanisms especially epigenetic regulation of mTEC homeostasis and TRA expression remain elusive. Here we show that the H3K27 demethylase Kdm6b is essential to maintain the postnatal thymic ...[more]