Ontology highlight
ABSTRACT:
SUBMITTER: Burke CM
PROVIDER: S-EPMC7508373 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Burke Cassandra M CM Mark Kenneth M K KMK Walsh Daniel J DJ Noble Geoffrey P GP Steele Alexander D AD Diack Abigail B AB Manson Jean C JC Watts Joel C JC Supattapone Surachai S
PLoS pathogens 20200908 9
Prions are unorthodox pathogens that cause fatal neurodegenerative diseases in humans and other mammals. Prion propagation occurs through the self-templating of the pathogenic conformer PrPSc, onto the cell-expressed conformer, PrPC. Here we study the conversion of PrPC to PrPSc using a recombinant mouse PrPSc conformer (mouse protein-only recPrPSc) as a unique tool that can convert bank vole but not mouse PrPC substrates in vitro. Thus, its templating ability is not dependent on sequence homolo ...[more]