Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC7509399 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Feng Junxia J Deng Yingying Y Fu Mengjiao M Hu Xueyuan X Luo Wenbo W Lu Zhiyu Z Dai Lupeng L Yang Huiying H Zhao Xiaodong X Du Zongmin Z Wen Bohai B Jiang Lingxiao L Zhou Dongsheng D Jiao Jun J Xiong Xiaolu X
Frontiers in cellular and infection microbiology 20200908
Plague, which is caused by <i>Yersinia pestis</i>, is one of the most dangerous infectious diseases. No FDA-approved vaccine against plague is available for human use at present. To improve the immune safety of <i>Y. pestis</i> EV76 based live attenuated vaccine and to explore the feasibility of aerosolized intratracheal inoculation (i.t.) route for vaccine delivery, a plasminogen activator protease (<i>pla</i>) gene deletion mutant of the attenuated <i>Y. pestis</i> strain EV76-B-SHU was constr ...[more]