Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC7519094 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Huang Yanyan Y Yin Chuanchun C Liu Jun J Feng Baomin B Ge Dongdong D Kong Liang L Ortiz-Morea Fausto Andres FA Richter Julia J Hauser Marie-Theres MT Wang Wen-Ming WM Shan Libo L He Ping P
Nature communications 20200925 1
Cell death is intrinsically linked with immunity. Disruption of an immune-activated MAPK cascade, consisting of MEKK1, MKK1/2, and MPK4, triggers cell death and autoimmunity through the nucleotide-binding leucine-rich repeat (NLR) protein SUMM2 and the MAPK kinase kinase MEKK2. In this study, we identify a Catharanthus roseus receptor-like kinase 1-like (CrRLK1L), named LETUM2/MEDOS1 (LET2/MDS1), and the glycosylphosphatidylinositol (GPI)-anchored protein LLG1 as regulators of mekk1-mkk1/2-mpk4 ...[more]