Ontology highlight
ABSTRACT:
SUBMITTER: Steiner A
PROVIDER: S-EPMC7560206 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
The EMBO journal 20200824 20
Sequence variants of the microglial expressed TREM2 (triggering receptor expressed on myeloid cells 2) are a major risk factor for late onset Alzheimer's disease. TREM2 requires a stable interaction with DAP12 in the membrane to initiate signaling, which is terminated by TREM2 ectodomain shedding and subsequent intramembrane cleavage by γ-secretase. To understand the structural basis for the specificity of the intramembrane cleavage event, we determined the solution structure of the TREM2 transm ...[more]