Ontology highlight
ABSTRACT:
SUBMITTER: Sherk AB
PROVIDER: S-EPMC2562281 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Sherk Andrea B AB Frigo Daniel E DE Schnackenberg Christine G CG Bray Jeffrey D JD Laping Nicholas J NJ Trizna Walter W Hammond Marlys M Patterson Jaclyn R JR Thompson Scott K SK Kazmin Dmitri D Norris John D JD McDonnell Donald P DP
Cancer research 20080901 18
Androgens, through their actions on the androgen receptor (AR), are required for the development of the prostate and contribute to the pathologic growth dysregulation observed in prostate cancers. Consequently, androgen ablation has become an essential component of the pharmacotherapy of prostate cancer. In this study, we explored the utility of targeting processes downstream of AR as an alternate approach for therapy. Specifically, we show that the serum and glucocorticoid-regulated kinase 1 (S ...[more]