Ontology highlight
ABSTRACT:
SUBMITTER: Wierda KDB
PROVIDER: S-EPMC7582164 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Wierda Keimpe D B KDB Toft-Bertelsen Trine L TL Gøtzsche Casper R CR Pedersen Ellis E Korshunova Irina I Nielsen Janne J Bang Marie Louise ML Kønig Andreas B AB Owczarek Sylwia S Gjørlund Michelle D MD Schupp Melanie M Bock Elisabeth E Sørensen Jakob B JB
Scientific reports 20201022 1
Classically, neurexins are thought to mediate synaptic connections through trans interactions with a number of different postsynaptic partners. Neurexins are cleaved by metalloproteases in an activity-dependent manner, releasing the soluble extracellular domain. Here, we report that in both immature (before synaptogenesis) and mature (after synaptogenesis) hippocampal neurons, the soluble neurexin-1β ectodomain triggers acute Ca<sup>2+</sup>-influx at the dendritic/postsynaptic side. In both cas ...[more]