Ontology highlight
ABSTRACT:
SUBMITTER: Adihou H
PROVIDER: S-EPMC7591920 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Adihou Hélène H Gopalakrishnan Ranganath R Förster Tim T Guéret Stéphanie M SM Gasper Raphael R Geschwindner Stefan S Carrillo García Carmen C Karatas Hacer H Pobbati Ajaybabu V AV Vazquez-Chantada Mercedes M Davey Paul P Wassvik Carola M CM Pang Jeremy Kah Sheng JKS Soh Boon Seng BS Hong Wanjin W Chiarparin Elisabetta E Schade Dennis D Plowright Alleyn T AT Valeur Eric E Lemurell Malin M Grossmann Tom N TN Waldmann Herbert H
Nature communications 20201027 1
Transcription factors are key protein effectors in the regulation of gene transcription, and in many cases their activity is regulated via a complex network of protein-protein interactions (PPI). The chemical modulation of transcription factor activity is a long-standing goal in drug discovery but hampered by the difficulties associated with the targeting of PPIs, in particular when extended and flat protein interfaces are involved. Peptidomimetics have been applied to inhibit PPIs, however with ...[more]