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Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential.

ABSTRACT: Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on the compounds' potential to be utilized as quality chemical biology probes.

SUBMITTER: Martin Moyano P

PROVIDER: S-EPMC7593917 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Cdc-Like Kinases (CLKs): Biology, Chemical Probes, and Therapeutic Potential.

Martín Moyano Paula P Němec Václav V Paruch Kamil K

International journal of molecular sciences 20201013 20

Protein kinases represent a very pharmacologically attractive class of targets; however, some members of the family still remain rather unexplored. The biology and therapeutic potential of cdc-like kinases (CLKs) have been explored mainly over the last decade and the first CLK inhibitor, compound SM08502, entered clinical trials only recently. This review summarizes the biological roles and therapeutic potential of CLKs and their heretofore published small-molecule inhibitors, with a focus on th ...[more]

PMID: 33066143

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