Self-Maintaining CD103⁺ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector Responses.

ABSTRACT: Enrichment of CD103⁺ tumor-infiltrating T lymphocytes (TIL) is associated with improved outcomes in patients. However, the characteristics of human CD103⁺ cytotoxic CD8⁺ T cells (CTL) and their role in tumor control remain unclear. We investigated the features and antitumor mechanisms of CD103⁺ CTLs by assessing T-cell receptor (TCR)-matched CD103⁺ and CD103^- cancer-specific CTL immunity in vitro and its immunophenotype ex vivo Interestingly, we found that differentiated CD103⁺ cancer-specific CTLs expressed the active form of TGFβ1 to continually self-regulate CD103 expression, without relying on external TGFβ1-producing cells. The presence of CD103 on CTLs improved TCR antigen sensitivity, which en

SUBMITTER: Abd Hamid M 

PROVIDER: S-EPMC7611226 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature