Ontology highlight
ABSTRACT:
SUBMITTER: Laptev I
PROVIDER: S-EPMC7641309 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Laptev Ivan I Shvetsova Ekaterina E Levitskii Sergey S Serebryakova Marina M Rubtsova Maria M Zgoda Victor V Bogdanov Alexey A Kamenski Piotr P Sergiev Petr P Dontsova Olga O
Nucleic acids research 20200801 14
Mammalian mitochondrial ribosomes contain a set of modified nucleotides, which is distinct from that of the cytosolic ribosomes. Nucleotide m4C840 of the murine mitochondrial 12S rRNA is equivalent to the dimethylated m4Cm1402 residue of Escherichia coli 16S rRNA. Here we demonstrate that mouse METTL15 protein is responsible for the formation of m4C residue of the 12S rRNA. Inactivation of Mettl15 gene in murine cell line perturbs the composition of mitochondrial protein biosynthesis machinery. ...[more]