Ontology highlight
ABSTRACT:
SUBMITTER: Yokoyama Y
PROVIDER: S-EPMC7657232 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Yokoyama Yuhki Y Hieda Miki M Nishioka Yu Y Matsumoto Ayaka A Higashi Satomi S Kimura Hiroshi H Yamamoto Hirofumi H Mori Masaki M Matsuura Shuji S Matsuura Nariaki N
Cancer science 20130515 7
Global histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types. Recent studies suggest that aberrant histone modifications play an important role in cancer. However, the effects of global epigenetic rearrangements on cell functions remain poorly understood. In this study, we show that the histone H3 lysine 9 (H3K9) methyltransferase SUV39H1 is clearly involved in regulating cell migration in vitro. Overexpression of wild-type SUV39H1, but not ...[more]