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A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions.


ABSTRACT: Apicomplexan parasites cause major human disease and food insecurity. They owe their considerable success to highly specialized cell compartments and structures. These adaptations drive their recognition, nondestructive penetration, and elaborate reengineering of the host's cells to promote their growth, dissemination, and the countering of host defenses. The evolution of unique apicomplexan cellular compartments is concomitant with vast proteomic novelty. Consequently, half of apicomplexan proteins are unique and uncharacterized. Here, we determine the steady-state subcellular location of thousands of proteins simultaneously within the globally prevalent apicomplexan parasite Toxoplasma gondii. This provides unprecedented comprehensive molecular definition of these unicellular eukaryotes and their specialized compartments, and these data reveal the spatial organizations of protein expression and function, adaptation to hosts, and the underlying evolutionary trajectories of these pathogens.

SUBMITTER: Barylyuk K 

PROVIDER: S-EPMC7670262 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions.

Barylyuk Konstantin K   Koreny Ludek L   Ke Huiling H   Butterworth Simon S   Crook Oliver M OM   Lassadi Imen I   Gupta Vipul V   Tromer Eelco E   Mourier Tobias T   Stevens Tim J TJ   Breckels Lisa M LM   Pain Arnab A   Lilley Kathryn S KS   Waller Ross F RF  

Cell host & microbe 20201013 5


Apicomplexan parasites cause major human disease and food insecurity. They owe their considerable success to highly specialized cell compartments and structures. These adaptations drive their recognition, nondestructive penetration, and elaborate reengineering of the host's cells to promote their growth, dissemination, and the countering of host defenses. The evolution of unique apicomplexan cellular compartments is concomitant with vast proteomic novelty. Consequently, half of apicomplexan prot  ...[more]

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