Ontology highlight
ABSTRACT:
SUBMITTER: Zhanghao K
PROVIDER: S-EPMC7674432 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Zhanghao Karl K Liu Wenhui W Li Meiqi M Wu Zihan Z Wang Xiao X Chen Xingye X Shan Chunyan C Wang Haoqian H Chen Xiaowei X Dai Qionghai Q Xi Peng P Jin Dayong D
Nature communications 20201118 1
Lipid membranes are found in most intracellular organelles, and their heterogeneities play an essential role in regulating the organelles' biochemical functionalities. Here we report a Spectrum and Polarization Optical Tomography (SPOT) technique to study the subcellular lipidomics in live cells. Simply using one dye that universally stains the lipid membranes, SPOT can simultaneously resolve the membrane morphology, polarity, and phase from the three optical-dimensions of intensity, spectrum, a ...[more]