Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC7726795 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Gao Jieqiong J Kurre Rainer R Rose Jaqueline J Walter Stefan S Fröhlich Florian F Piehler Jacob J Reggiori Fulvio F Ungermann Christian C
EMBO reports 20201007 12
The mechanism and regulation of fusion between autophagosomes and lysosomes/vacuoles are still only partially understood in both yeast and mammals. In yeast, this fusion step requires SNARE proteins, the homotypic vacuole fusion and protein sorting (HOPS) tethering complex, the RAB7 GTPase Ypt7, and its guanine nucleotide exchange factor (GEF) Mon1-Ccz1. We and others recently identified Ykt6 as the autophagosomal SNARE protein. However, it has not been resolved when and how lipid-anchored Ykt6 ...[more]