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Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation.

ABSTRACT: The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78?% yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing molecules into value-added scaffolds.

SUBMITTER: Gao M

PROVIDER: S-EPMC7756308 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation.

Gao Mélissa M Chen Mu-Yi MY Pannecoucke Xavier X Jubault Philippe P Besset Tatiana T

Chemistry (Weinheim an der Bergstrasse, Germany) 20201103 67

The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing molecules into value-added scaffolds. ...[more]

PMID: 32833317

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