Ontology highlight
ABSTRACT:
SUBMITTER: DiMaggio E
PROVIDER: S-EPMC7771324 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
DiMaggio Elizabeth E Zhou Jun-Min JM Caddell Ryan R Tombleson Rebecca R Perkins Janelle J Anasetti Claudio C Khimani Farhad F Pidala Joseph J Nishihori Taiga T Perez Lia L Betts Brian B Fernandez Hugo F HF Mishra Asmita A
Leukemia & lymphoma 20200305 7
Optimal conditioning chemotherapy for patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) remains uncertain. Myeloablative regimens such as fludarabine/busulfan are favored over reduced-intensity fludarabine/melphalan (Flu/Mel); however, it is not known if Flu/Mel is inferior. We analyzed hematopoietic cell transplantation recipients with AML and MDS who received fludarabine with once-daily intravenous busulfan targeted to either area under the curve (AUC) 5300 µM*L/min ...[more]