Ontology highlight
ABSTRACT:
SUBMITTER: Molnar K
PROVIDER: S-EPMC7824826 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pharmaceutics 20210105 1
By being an antagonist of glutamate and other receptors, kynurenic acid serves as an endogenous neuroprotectant in several pathologies of the brain. Unfortunately, systemic administration of kynurenic acid is hindered by its low permeability through the blood-brain barrier. One possibility to overcome this problem is to use analogues with similar biological activity as kynurenic acid, but with an increased permeability through the blood-brain barrier. We synthesized six novel aminoalkylated amid ...[more]