Ontology highlight
ABSTRACT:
SUBMITTER: Gurard-Levin ZA
PROVIDER: S-EPMC7834858 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Gurard-Levin Zachary A ZA Liu Cheng C Jekle Andreas A Jaisinghani Ruchika R Ren Suping S Vandyck Koen K Jochmans Dirk D Leyssen Pieter P Neyts Johan J Blatt Lawrence M LM Beigelman Leonid L Symons Julian A JA Raboisson Pierre P Scholle Michael D MD Deval Jerome J
Antiviral research 20200905
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The coronavirus 3-chymotrypsin-like cysteine protease (3CLpro) controls replication and is therefore considered a major target for antiviral discovery. This study describes the evaluation of SARS-CoV-2 3CLpro inhibitors in a novel self-assembled monolayer desorption ionization mass spectrometry (SAMDI-MS) enzymatic assay. Compared with a traditional FRET readout, the label-free ...[more]