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Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?

ABSTRACT: While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS). In this study, the challenging VVIA tetrapeptide was synthesized by ball-milling, in solution, and on solid support. The three strategies were then compared in terms of yield, purity, reaction time and environmental impact. The results obtained enabled to draw some strengths and weaknesses of each strategy, and to foresee what will have to be implemented to build more efficient and sustainable peptide syntheses in the near future.

SUBMITTER: Maurin O

PROVIDER: S-EPMC7874854 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Peptide synthesis: ball-milling, in solution, or on solid support, what is the best strategy?

Maurin Ophélie O Verdié Pascal P Subra Gilles G Lamaty Frédéric F Martinez Jean J Métro Thomas-Xavier TX

Beilstein journal of organic chemistry 20171006

While presenting particularly interesting advantages, peptide synthesis by ball-milling was never compared to the two traditional strategies, namely peptide syntheses in solution and on solid support (solid-phase peptide synthesis, SPPS). In this study, the challenging VVIA tetrapeptide was synthesized by ball-milling, in solution, and on solid support. The three strategies were then compared in terms of yield, purity, reaction time and environmental impact. The results obtained enabled to draw ...[more]

PMID: 33613776

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