Ontology highlight
ABSTRACT:
SUBMITTER: Dai J
PROVIDER: S-EPMC7880682 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Dai Jian J Li Ying Y Kametani Fuyuki F Cui Xiaoran X Igarashi Yuichi Y Huo Jia J Miyahara Hiroki H Mori Masayuki M Higuchi Keiichi K
eLife 20210126
Curcumin is a polyphenol compound that exhibits multiple physiological activities. To elucidate the mechanisms by which curcumin affects systemic amyloidosis, we investigated amyloid deposition and molecular changes in a mouse model of amyloid apolipoprotein A-II (AApoAII) amyloidosis, in which mice were fed a curcumin-supplemented diet. Curcumin supplementation for 12 weeks significantly increased AApoAII amyloid deposition relative to controls, especially in the liver and spleen. Liver weights ...[more]