Myocardial Infarction and AGT p.Thr174Met Polymorphism: A Meta-Analysis of 7657 Subjects.
Ontology highlight
ABSTRACT: Background
It has been suggested that the angiotensinogen (AGT) gene rs4762 (p.Thr174Met) polymorphism might be associated with myocardial infarction (MI) risk, but the study results are still debatable. Objective and Methods. In order to explore the relationship between AGT p.Thr174Met polymorphism and MI risk, the current meta-analysis involving 7657 subjects from 11 individual studies was conducted.Results
A significant association between AGT p.Thr174Met polymorphism and MI was found under recessive (OR: 2.26, 95% CI: 1.35-3.77, P = 0.002), dominant (OR: 1.131, 95% CI: 1.016-1.260, P = 0.024), codominant (OR: 2.198, 95% CI: 1.334-3.621, P = 0.002), and additive (OR: 1.363, 95% CI: 1.132-1.641, P = 0.001) genetic models. In the Asian subgroup, significantly increased MI risk was found under all genetic models (P < 0.05). No significant association between AGT p.Thr174Met polymorphism and MI was found under all genetic models in the Caucasian subgroup (P > 0.05).Conclusions
AGT p.Thr174Met variant might increase MI risk, especially within the Asian population. The Met174 allele of AGT p.Thr174Met might confer the risk for MI.
SUBMITTER: Li YY
PROVIDER: S-EPMC8112938 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:BackgroundResearches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting.Objective and methodsA meta-analysis was conducted to investigate the association between eNOS G894T polymorphism and MI. Published studies from PubMed, Embase, CNKI and CBM databases were retrieved. The pooled odds ratios (ORs) for the association between eNOS G894T polymorphism and MI and their corresponding 95% confidence intervals (CIs) were estimated using the random- or fixed- effect model.ResultsA total of 34 studies including 8229 cases and 12839 controls were identified for the meta-analysis. The eNOS G894T polymorphism was significantly associated with MI under a homozygous genetic model (OR?=?1.41, 95% CI?=?1.08-1.84; P?=?0.012), a recessive genetic model (OR?=?1.35, 95% CI?=?1.06-1.70; P?=?0.014), a dominant genetic model (OR?=?1.18, 95% CI?=?1.04-1.34; P?=?0.009). In the subgroup analysis by ethnicity (non-Asian and Asian), no significant association was observed between eNOS G894T polymorphism and MI risk among non-Asians (P>0.05), but a positive significant association was found among Asians (P<0.05).ConclusionsThe eNOS G894T polymorphism is associated with increased MI risk in Asians. The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI.
| S-EPMC3907515 | biostudies-literature
Project description:A number of case-control studies have been conducted to clarify the association between ApoE polymorphisms and myocardial infarction (MI); however, the results are inconsistent. This meta-analysis was performed to clarify this issue using all the available evidence. Searching in PubMed retrieved all eligible articles. A total of 33 studies were included in this meta-analysis, including 18752 MI cases and 18963 controls. The pooled analysis based on all included studies showed that the MI patients had a decreased frequency of the ?2 allele (OR?=?0.78, 95% CI?=?0.70-0.87) and an increased frequency of the ?4 allele (OR?=?1.15, 95% CI?=?1.10-1.20); The results also showed a decreased susceptibility of MI in the ?2?3 vs. ?3?3 analysis (OR?=?0.79, 95% CI?=?0.68-0.90) and in the ?2 vs. ?3 analysis (OR?=?0.78, 95% CI?=?0.69-0.89), an increased susceptibility of MI in the ?3?4 vs. ?3?3 analysis (OR?=?1.26, 95% CI?=?1.12-1.41), in the ?4 vs. ?3 analysis (OR?=?1.22, 95% CI?=?1.12-1.32) and in the ?4?4 vs. ?3?3 analysis (OR?=?1.59, 95% CI?=?1.15-2.19). However, there were no significant associations among polymorphisms and MI for the following genetic models: frequency of the ?3 allele (OR?=?0.99, 95% CI?=?0.96-1.02); ?2?2 vs. ?3?3 analysis (OR?=?0.73, 95% CI?=?0.40-1.32); or ?2?4 vs. ?3?3 analysis (OR?=?1.10, 95% CI?=?0.99-1.21). Our results suggested that the ?4 allele of ApoE is a risk factor for the development of MI and the ?2 allele of ApoE is a protective factor in the development of MI.
| S-EPMC4128680 | biostudies-literature
Project description:Many studies have reported that the IL-1??+?3954C/T polymorphism (rs1143634) is related to myocardial infarction (MI). To classify the association between IL-1??+?3954C/T and MI susceptibility, we performed a meta-analysis.We retrieved relevant literature from electronic databases (Embase, PubMed, Cochrane, and Web of Science). Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated with a fixed effect model or a random effect model. Sensitivity analysis and publication bias results are also presented.Nine eligible studies (2299 controls and 2203 cases) were included. The pooled results showed a significant relationship between MI and IL-1??+?3954C/T in an allelic comparison (T vs C: OR?=?1.13, 95% CI 1.02-1.25, I?=?0%, PH?=?.448) and in a dominant model (TC?+?TT vs CC: OR?=?1.15, 95% CI 1.02-1.30, I?=?0%, PH?=?.880). Ethnic subgroup analysis showed similar results in Caucasian populations: an allelic comparison (T vs C: OR?=?1.16, 95% CI 1.04-1.29, I?=?0%, PH?=?.701), homozygote model (TT vs CC: OR?=?1.36, 95% CI 1.04-1.79, I?=?0%, PH?=?.673), and dominant model (TC?+?TT vs CC: OR?=?1.17, 95% CI 1.02-1.33, I?=?0%, PH?=?.851). In addition, similar effects remained in subgroups analyses of high-quality studies and PCR-RFLP (restriction fragment length polymorphism) data.Our meta-analysis proved that IL-1??+?3954C/T is associated with MI susceptibility, especially among Caucasian populations.
| S-EPMC6078675 | biostudies-literature
Project description:A number of studies have been conducted to explore the association between the cholesteryl ester transfer protein (CETP) TaqIB polymorphism and risk of myocardial infarction (MI); however, the results are inconsistent. Therefore, we conducted this meta-analysis to clarify the issue based on all the data available.Eligible studies were retrieved by searching PubMed, Embase, Web of Science, and Google Scholar. We calculated the crude odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) to assess the association between the TaqIB polymorphism and risk of MI.We included 13 studies involving 8733 MI cases and 8573 controls in the meta-analysis. The pooled results from all included studies showed decreased MI risk in the analysis of the B2B2 versus B1B1 (OR?=?0.78, 95% CI?=?0.68-0.91), dominant (OR?=?0.88, 95% CI?=?0.77-0.99), and recessive genetic models (OR?=?0.84, 95% CI?=?0.78-0.91). The frequency of the B2B2 genotype in MI patients was lower (OR?=?0.87, 95% CI?=?0.81-0.94). However, there was no significant association in the B1B2 versus B1B1 analysis (OR?=?0.92, 95% CI?=?0.81-1.05) and no significant difference for the B1B1 genotype (OR?=?1.04, 95% CI?=?0.98-1.11) and B1B2 genotype (OR?=?1.03, 95% CI?=?0.97-1.08). Cumulative analysis confirmed these results.Our results suggest that the B2B2 genotype of the CETP TaqIB polymorphism is a protective factor against the development of MI.
| S-EPMC4616386 | biostudies-literature
Project description:ObjectiveCurrent findings on the association between MMP-9 rs3918242 and susceptibility to myocardial infarction (MI) are inconsistent, and their definite relationship is discussed in this meta-analysis.MethodsEligible literatures reporting MMP-9 rs3918242 and susceptibility to MI were searched in PubMed, Cochrane Library, CNRI, and VIP using keywords such as "MMP-9", "matrix metallopeptidase-9" and "myocardial infarction", "acute myocardial infarction", "AMI", and "polymorphism". Data from eligible literatures were extracted for calculating OR and corresponding 95% CI using RevMan 5.3 and STATA12.0.ResultsTen independent literatures reporting MMP-9 rs3918242 and susceptibility to MI were enrolled. Compared with subjects carrying CT&TT genotype of MMP-9 rs3918242, susceptibility to MI was lower in those carrying CC genotype (OR = 1.49, 95%CI = 1.19-1.86, P = 0.0004). Such a significance was observed in the overdominant (OR = 1.27, 95%CI = 1.14-1.41, P < 0.0001) and allele genetic models (OR = 1.43, 95%CI = 1.17-1.74, P = 0.0005) as well. This finding was also valid in the Asian population.ConclusionsMutation on MMP-9 rs3918242 has a potential relevance with susceptibility to MI.
| S-EPMC8783703 | biostudies-literature
Project description:BACKGROUND:The PlA2 polymorphism of glycoprotein IIIa (GPIIIa) has been previously identified as being associated with myocardial infarction (MI), but whether this represents a true association is entirely unclear due to differences in findings from different studies. We performed a meta-analysis to evaluate whether this polymorphism is a risk factor for MI. METHODS:Electronic databases (MEDLINE and EMBASE) were searched for all articles evaluating genetic polymorphisms of GPIIIa. For studies where acute coronary events were recorded in association with genetic analysis, pooled odds ratios (ORs) were calculated using fixed-effects and random-effects models. The primary outcome measure was MI, and a secondary analysis was also performed for acute coronary syndromes (ACS) more generally. FINDINGS:57 studies were eligible for statistical analysis and included 17,911 cases and 24,584 controls. Carriage of the PlA2 allele was significantly associated with MI (n?=?40,692; OR 1.077, 95% CI 1.024-1.132; p?=?0.004) but with significant publication bias (p?=?0.040). The degree of association with MI increased with decreasing age of subjects (?45 years old: n?=?9,547; OR 1.205, 95% CI 1.067-1.360; p?=?0.003) and with adjustment of data for conventional cardiovascular risk factors (n?=?12,001; OR 1.240, 95% CI 1.117-1.376; p<0.001). There was a low probability of publication bias for these subgroup analyses (all p<0.05). CONCLUSIONS:The presence of significant publication bias makes it unclear whether the association between carriage of the PlA2 allele and MI is true for the total population studied. However for younger subjects, the relative absence of conventional cardiovascular risk factors results in a significant association between carriage of the PlA2 allele and MI.
| S-EPMC4079717 | biostudies-literature
Project description:BackgroundMyocardial infarction (MI) is the major cause of death by disease in the world. Many studies have identified the associations between matrix metalloproteinase 9 (MMP9) C-1562T polymorphisms and MI. However, the results remain inconclusive. To clarify the role of MMP9 C-1562T polymorphism in MI risk, we conducted a systematic review and large-scale meta-analysis.MethodsStudies published between January 2005 and March 2014 were obtained from the electronic databases PubMed, Medline, and Embase. The odds ratios (ORs) with 95% CIs were calculated for comparisons of the alleles and genotypes in the overall population and in ethnicity subgroups to measure the strength of genetic associations.ResultsA total of 7 related studies, including 3952 MI cases and 4977 healthy control subjects were included in our meta-analysis. Our results show a statistically significant association between T allele and MI in the overall population (OR = 1.23; 95% CI, 1.02-1.48; P = 0.03). The risk of MI was also significantly higher in patients carrying the T allele (TC + TT genotypes) than in those with the CC genotype (P < 0.05). In stratified analysis by ethnicity, we found the T allele was strongly associated with MI in white populations, whereas in Asian populations there appeared no significant association.ConclusionsOur data show that the MMP9 C-1562T polymorphism is a risk factor associated with increased MI susceptibility in the total population and white populations, although no significant association was observed in Asians populations. Further studies with larger sample sizes and assessing gene-gene and gene-environment interactions are required.
| S-EPMC4461879 | biostudies-literature
Project description:BACKGROUND:Recent studies have demonstrated that acute myocardial infarction induces a distinctive miRNA signature, suggesting that miRNAs may serve as diagnostic markers. Although many studies have investigated the use of miRNAs in the detection of cardiac injury, some had small sample sizes (<100 patients) or reported different results for the same miRNA. Here, the role of circulating miRNAs for use as biomarkers of myocardial infarction is summarized and analyzed. METHODS AND RESULTS:Medline, SCI, Embase, and Cochrane databases were searched up to January 2013 for studies that evaluated associations between miRNAs and myocardial infarction. Relevant publications were identified by searching for combinations of "myocardial infarction," "miRNAs," and their synonyms. Methodological quality was scored using a standardized list of criteria, and diagnostic performance was assessed using estimates of test sensitivity and specificity. These values were summarized using summary receiver-operating characteristic curves. Nineteen studies met the inclusion criteria: 15 studies reported sensitivity, specificity, and AUC, but 4 studies did not. Total miRNAs: sensitivity: 0.78 (95%CI: 0.77-0.80; P?=?0.0000); specificity: 0.82 (95%CI: 0.80-0.83; P?=?0.0000). miR-499: sensitivity: 0.88 (95%CI:0.86-0.90; P?=?0.0000); specificity: 0.87 (95%CI:0.84-0.90; P?=?0.0000). miR-1: sensitivity: 0.63 (95%CI:0.59-0.66; P?=?0.0000); specificity: 0.76 (95%CI:0.71-0.80; P?=?0.0000). miR-133a: sensitivity: 0.89 (95%CI:0.83-0.94; P?=?0.0047); specificity: 0.87 (95%CI:0.79-0.92; P?=?0.0262). miR-208b: sensitivity: 0.78 (95%CI:0.76-0.81; P?=?0.0581); specificity: 0.88 (95%CI:0.84-0.91; P?=?0.0000). The correlation between miRNAs and other diagnostic biomarkers of myocardial infarction was obvious. CONCLUSION:MiRNAs, especially miR-499 and miR-133a, may be suitable for use as diagnostic biomarkers of myocardial infarction.
| S-EPMC3922900 | biostudies-literature
Project description:G20210A polymorphism (rs1799963) within the prothrombin gene is associated with a higher circulation level of prothrombin, thus increasing the likelihood of developing myocardial infarction (MI). Opinions differ regarding the correlation between prothrombin G20210A genotype and MI risk, which prompted us to conduct a meta-analysis to determine this association. PubMed, EMBASE, Web of Science and CNKI were searched for pertinent reports. A total of 34 studies involving 14 611 MI cases and 84 358 controls were analyzed in this quantitative analysis. We found a statistically significant association between prothrombin G20210A polymorphism and MI in the allele model (A vs. G, OR = 1.43, 95%CI: 1.18-1.72), heterozygote model (GA vs. GG, OR = 1.41, 95%CI: 1.16-1.72) and dominant model (GA + AA vs. GG, OR = 1.41, 95%CI: 1.15-1.72). The association remains significant in Caucasians but not in non-Caucasians. Moreover, prothrombin G20210A polymorphism increases MI risk in an age-related manner. A further significant association was found in a subpopulation younger than 55 years (allele model, OR = 1.76, 95%CI: 1.32-2.35; heterozygote model, OR = 1.70, 95%CI: 1.24-2.33; dominant model, OR = 1.70, 95%CI: 1.24-2.34). Sensitivity analysis and publication bias analysis revealed stable and statistically robust results. Our meta-analysis demonstrated that prothrombin G20210A polymorphism may represent a risk factor for MI.
| S-EPMC5648836 | biostudies-literature
Project description:ObjectiveGenetic components substantially contribute to the development of myocardial infarction (MI), and R353Q polymorphism (rs6046) in FVII gene has been suspected to be associated with the risk of MI.MethodsA meta-analysis was conducted on the links between R353Q polymorphism and the susceptibility of MI. A comprehensive literature search was performed on 8 electronic databases. The main effects of the genotypes were estimated using a logistic regression approach. The odds ratios with 95% confidence intervals were calculated using the conventional summary method meta-analysis. The possible sources of heterogeneity among the included studies were explored using meta-regression analysis and subgroup analysis.ResultsA total of 18 eligible case-control studies, comprising of 4701 cases and 5329 controls, were included. No overall statistical relationship was identified between R353Q and MI by any of the genetic models. The meta-regression demonstrated that the Asian population, body mass index (BMI) category, and diabetes affected the heterogeneity. In addition, subgroup analyses showed that heterogeneities were identified in Asian population and BMI category, which highly agree with the results of meta-regression.ConclusionsThe current meta-analysis suggested that R353Q polymorphism was not associated with the MI risk. Asian population, BMI category, and diabetes might be related to the incidence of MI. However, large-scale, case-control studies with rigorous designs are essential to provide accurate evidence.
| S-EPMC6181591 | biostudies-literature