Ontology highlight
ABSTRACT:
SUBMITTER: Burugupalli S
PROVIDER: S-EPMC8150115 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Burugupalli Satvika S Almeida Catarina F CF Smith Dylan G M DGM Shah Sayali S Patel Onisha O Rossjohn Jamie J Uldrich Adam P AP Godfrey Dale I DI Williams Spencer J SJ
Chemical science 20200114 8
Natural killer T cells express T cell receptors (TCRs) that recognize glycolipid antigens in association with the antigen-presenting molecule CD1d. Here, we report the concise chemical synthesis of a range of saturated and unsaturated α-glucosyl and α-glucuronosyl diacylglycerides of bacterial and fungal origins from allyl α-glucoside with Jacobsen kinetic resolution as a key step. These glycolipids are recognized by a classical type I NKT TCR that uses an invariant Vα14-Jα18 TCR α-chain, but al ...[more]