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Stereo-controlled anti-hydromagnesiation of aryl alkynes by magnesium hydrides.

ABSTRACT: A concise protocol for anti-hydromagnesiation of aryl alkynes was established using 1 : 1 molar combination of sodium hydride (NaH) and magnesium iodide (MgI₂) without the aid of any transition metal catalysts. The resulting alkenylmagnesium intermediates could be trapped with a series of electrophiles, thus providing facile accesses to stereochemically well-defined functionalized alkenes. Mechanistic studies by experimental and theoretical approaches imply that polar hydride addition from magnesium hydride (MgH₂) is responsible for the process.

SUBMITTER: Wang B

PROVIDER: S-EPMC8159320 | biostudies-literature |

REPOSITORIES: biostudies-literature

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