Ontology highlight
ABSTRACT:
SUBMITTER: Zhao P
PROVIDER: S-EPMC8252103 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Zhao Pengkun P Huo Shuaidong S Fan Jilin J Chen Junlin J Kiessling Fabian F Boersma Arnold J AJ Göstl Robert R Herrmann Andreas A
Angewandte Chemie (International ed. in English) 20210519 26
The regulation of enzyme activity is a method to control biological function. We report two systems enabling the ultrasound-induced activation of thrombin, which is vital for secondary hemostasis. First, we designed polyaptamers, which can specifically bind to thrombin, inhibiting its catalytic activity. With ultrasound generating inertial cavitation and therapeutic medical focused ultrasound, the interactions between polyaptamer and enzyme are cleaved, restoring the activity to catalyze the con ...[more]