Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
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ABSTRACT:
SUBMITTER: Vilella F
PROVIDER: S-EPMC8385818 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Publications
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
Vilella F F Wang W W Moreno I I Roson B B Quake S R SR Simon C C
Human reproduction (Oxford, England) 20210901 10
<h4>Study question</h4>Are SARS-CoV-2 canonical cell entry machinery, consisting of ACE2, TMPRSS2, NRP1 and LY6E, or alternative potential cell entry machinery, consisting of BSG, ANPEP, CD209, CLEC4G, TMPRSS4, TMPRSS11A, FURIN, CTSB, CTSL and IFITM1, expressed in the human endometrium across the menstrual cycle?<h4>Summary answer</h4>Analysis of cell entry factors for SARS-CoV-2 by single-cell RNA-sequencing (scRNAseq) in the preconceptional human endometrium reveals low risk of infection.<h4>W ...[more]
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