Unknown

Dataset Information

0

Before the "cytokine storm": Boosting efferocytosis as an effective strategy against SARS-CoV-2 infection and associated complications.


ABSTRACT: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is responsible for the ongoing COVID-19 pandemic, and causes many health complications, including major lung diseases. Besides investigations into the virology of SARS-CoV-2, understanding the immunological routes underlying the clinical manifestations of COVID-19 is important for developing effective therapeutic interventions. The clearance of SARS-CoV-2-infected apoptotic cells by professional efferocytes, through a process termed as 'efferocytosis', is essential for maintaining tissue homeostasis, and reducing the chances of health complications caused by SARS-CoV-2 infection. In this review, we focus on the cellular events leading to engagement of the SARS-CoV-2 with type 2 alveolar cells, and how SARS-COV-2 infection impairs the macrophage anti-inflammatory programming. We also discuss accounts of impaired efferocytosis, and the "cytokine storm" which occur concomitantly with the SARS-CoV-2 infection. Finally, we propose how targeting impaired efferocytosis, due to the SARS-CoV-2 infection, may be a beneficial therapeutic strategy to combat COVID-19, and its complications.

SUBMITTER: Dutta S 

PROVIDER: S-EPMC8741331 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7976727 | biostudies-literature
| S-EPMC7583619 | biostudies-literature
| S-EPMC9454268 | biostudies-literature
| S-EPMC10322692 | biostudies-literature
| S-EPMC10953344 | biostudies-literature
| S-EPMC7828218 | biostudies-literature
| S-EPMC7799318 | biostudies-literature
| S-EPMC9031737 | biostudies-literature
| S-EPMC9751040 | biostudies-literature
| S-EPMC8308097 | biostudies-literature