Ontology highlight
ABSTRACT:
SUBMITTER: Gadomski S
PROVIDER: S-EPMC9033279 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Gadomski Stephen S Fielding Claire C García-García Andrés A Korn Claudia C Kapeni Chrysa C Ashraf Sadaf S Villadiego Javier J Toro Raquel Del RD Domingues Olivia O Skepper Jeremy N JN Michel Tatiana T Zimmer Jacques J Sendtner Regine R Dillon Scott S Poole Kenneth E S KES Holdsworth Gill G Sendtner Michael M Toledo-Aral Juan J JJ De Bari Cosimo C McCaskie Andrew W AW Robey Pamela G PG Méndez-Ferrer Simón S
Cell stem cell 20220310 4
The autonomic nervous system is a master regulator of homeostatic processes and stress responses. Sympathetic noradrenergic nerve fibers decrease bone mass, but the role of cholinergic signaling in bone has remained largely unknown. Here, we describe that early postnatally, a subset of sympathetic nerve fibers undergoes an interleukin-6 (IL-6)-induced cholinergic switch upon contacting the bone. A neurotrophic dependency mediated through GDNF-family receptor-α2 (GFRα2) and its ligand, neurturin ...[more]