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Scalemic myrionsumamide A, tetracyclic skeleton alkaloids from Myrioneuron effusum.

ABSTRACT: Investigation of the alkaloids from Myrioneuron effusum leads to the isolation of myrionsumamide A (1), a pair of enantiomeric alkaloids with an unprecedented tetracyclic system skeleton. These two alkaloids were separated by chiral HPLC with a ratio of 3 : 5 from the scalemic mixture. Their structures including absolute configurations were determined by NMR spectroscopy, X-ray diffraction data and ECD calculations. Both (+)-1 and (-)-1 showed antibacterial activity against Staphylococcus aureus with MIC at 7.81 μg ml^-1.

SUBMITTER: Zhang JH

PROVIDER: S-EPMC9527643 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Scalemic myrionsumamide A, tetracyclic skeleton alkaloids from Myrioneuron effusum.

Zhang Jia-Hui JH Cao Mingming M Zhang Yu Y Li Xiao-Hui XH Gu Yu-Cheng YC Li Xiao-Nian XN Di Ying-Tong YT Hao Xiao-Jiang XJ

RSC advances 20220901 43

Investigation of the alkaloids from Myrioneuron effusum leads to the isolation of myrionsumamide A (1), a pair of enantiomeric alkaloids with an unprecedented tetracyclic system skeleton. These two alkaloids were separated by chiral HPLC with a ratio of 3 : 5 from the scalemic mixture. Their structures including absolute configurations were determined by NMR spectroscopy, X-ray diffraction data and ECD calculations. Both (+)-1 and (-)-1 showed antibacterial activity against Staphylococ ...[more]

PMID: 36320238

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