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Metabolic contrast agents produced from transported solid 13C-glucose hyperpolarized via dynamic nuclear polarization.

ABSTRACT: Magnetic Resonance Imaging combined with hyperpolarized 13C-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolarization equipment is expensive, technically demanding and needs to be installed on-site for the end-user. In this work, we provide a robust methodology that allows remote production of the hyperpolarized 13C-labelled metabolic contrast agents. The methodology, built on photo-induced thermally labile radicals, allows solid sample extraction from the hyperpolarization equipment and several hours' lifetime of the 13C-labelled metabolic contrast agents at appropriate storage/transport conditions. Exemplified with [U-13C, d7]-D-glucose, we remotely produce hyperpolarized 13C-labelled metabolic contrast agents and generate above 10,000-fold liquid-state Magnetic Resonance signal enhancement at 9.4 T, keeping on-site only a simple dissolution device.

SUBMITTER: Capozzi A 

PROVIDER: S-EPMC9814755 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Metabolic contrast agents produced from transported solid <sup>13</sup>C-glucose hyperpolarized via dynamic nuclear polarization.

Capozzi Andrea A   Kilund Jan J   Karlsson Magnus M   Patel Saket S   Pinon Arthur Cesar AC   Vibert François F   Ouari Olivier O   Lerche Mathilde H MH   Ardenkjær-Larsen Jan Henrik JH  

Communications chemistry 20210623 1

Magnetic Resonance Imaging combined with hyperpolarized <sup>13</sup>C-labelled metabolic contrast agents produced via dissolution Dynamic Nuclear Polarization can, non-invasively and in real-time, report on tissue specific aberrant metabolism. However, hyperpolarization equipment is expensive, technically demanding and needs to be installed on-site for the end-user. In this work, we provide a robust methodology that allows remote production of the hyperpolarized <sup>13</sup>C-labelled metaboli  ...[more]

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