CryoEM structure of human LRRC8A
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ABSTRACT:
SUBMITTER: Osamu Nureki
PROVIDER: EMPIAR-10196 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of the human volume-regulated anion channel LRRC8.
Kasuya Go G Nakane Takanori T Yokoyama Takeshi T Jia Yanyan Y Inoue Masato M Watanabe Kengo K Nakamura Ryoki R Nishizawa Tomohiro T Kusakizako Tsukasa T Tsutsumi Akihisa A Yanagisawa Haruaki H Dohmae Naoshi N Hattori Motoyuki M Ichijo Hidenori H Yan Zhiqiang Z Kikkawa Masahide M Shirouzu Mikako M Ishitani Ryuichiro R Nureki Osamu O
Nature structural & molecular biology 20180820 9
Maintenance of cell volume against osmotic change is crucial for proper cell functions. Leucine-rich repeat-containing 8 proteins are anion-selective channels that extrude anions to decrease the cell volume on cellular swelling. Here, we present the structure of human leucine-rich repeat-containing 8A, determined by single-particle cryo-electron microscopy. The structure shows a hexameric assembly, and the transmembrane region features a topology similar to gap junction channels. The LRR region, ...[more]
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