Dataset Information
LRRC8A-DCPIB in MSP1E3D1 nanodiscs
Ontology highlight
ABSTRACT:
SUBMITTER: Stephen G Brohawn
PROVIDER: EMPIAR-10258 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
eLife 20190218
Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we present single-particle cryo-electron microscopy structures of <i>Mus musculus</i> LRRC8A in complex with the inhibitor DCPIB reconstituted in lipid nanodiscs. DCPIB plugs the channel like a cork in a bottle - binding in the extracellular selectivity fi ...[more]