Dataset Information
Single particle cryoEM of Streptococcus thermophilus SHP pheromone receptor Rgg3 in complex with SHP3
Ontology highlight
ABSTRACT:
SUBMITTER: Vasileios I Petrou
PROVIDER: EMPIAR-10535 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure-function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay.
Proceedings of the National Academy of Sciences of the United States of America 20200909 39
Regulator gene of glucosyltransferase (Rgg) family proteins, such as Rgg2 and Rgg3, have emerged as primary quorum-sensing regulated transcription factors in <i>Streptococcus</i> species, controlling virulence, antimicrobial resistance, and biofilm formation. Rgg2 and Rgg3 function is regulated by their interaction with oligopeptide quorum-sensing signals called short hydrophobic peptides (SHPs). The molecular basis of Rgg-SHP and Rgg-target DNA promoter specificity was unknown. To close this ga ...[more]