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Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with progressive supranuclear palsy

ABSTRACT:

SUBMITTER: Yang Shi

PROVIDER: EMPIAR-10765 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structure-based classification of tauopathies.

Shi Yang Y Zhang Wenjuan W Yang Yang Y Murzin Alexey G AG Falcon Benjamin B Kotecha Abhay A van Beers Mike M Tarutani Airi A Kametani Fuyuki F Garringer Holly J HJ Vidal Ruben R Hallinan Grace I GI Lashley Tammaryn T Saito Yuko Y Murayama Shigeo S Yoshida Mari M Tanaka Hidetomo H Kakita Akiyoshi A Ikeuchi Takeshi T Robinson Andrew C AC Mann David M A DMA Kovacs Gabor G GG Revesz Tamas T Ghetti Bernardino B Hasegawa Masato M Goedert Michel M Scheres Sjors H W SHW

Nature 20210929 7880

The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease1,2, Pick's disease3, chronic traumatic encephalopathy4 and corticobasal degeneration5 are distinct. Here we show that the structures of tau filaments from progressive supranuclear palsy (PSP) define a new ...[more]

PMID: 34588692

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