Dataset Information
Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with pathological aging of amyloid-β 42 filaments
Ontology highlight
ABSTRACT:
SUBMITTER: Yang Yang
PROVIDER: EMPIAR-10917 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of amyloid-β 42 filaments from human brains.
Science (New York, N.Y.) 20220113 6577
Filament assembly of amyloid-β peptides ending at residue 42 (Aβ42) is a central event in Alzheimer’s disease. Here, we report the cryo–electron microscopy (cryo-EM) structures of Aβ42 filaments from human brains. Two structurally related S-shaped protofilament folds give rise to two types of filaments. Type I filaments were found mostly in the brains of individuals with sporadic Alzheimer’s disease, and type II filaments were found in individuals with familial Alzheimer’s disease and other cond ...[more]