Dataset Information
Single particle cryo-EM dataset of sarkosyl-insoluble fraction from the frontal cortex of an individual with mutation +16 in intron 10 of MAPT
Ontology highlight
ABSTRACT:
SUBMITTER: Yang Shi
PROVIDER: EMPIAR-10769 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure-based classification of tauopathies.
Nature 20210929 7880
The ordered assembly of tau protein into filaments characterizes several neurodegenerative diseases, which are called tauopathies. It was previously reported that, by cryo-electron microscopy, the structures of tau filaments from Alzheimer's disease<sup>1,2</sup>, Pick's disease<sup>3</sup>, chronic traumatic encephalopathy<sup>4</sup> and corticobasal degeneration<sup>5</sup> are distinct. Here we show that the structures of tau filaments from progressive supranuclear palsy (PSP) define a new ...[more]