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CryoEM SPA dataset for NB21, SARS-Cov-2 and NB105 trimeric complex

ABSTRACT:

SUBMITTER: Wei Huang 

PROVIDER: EMPIAR-10837 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes.

Sun Dapeng D   Sang Zhe Z   Kim Yong Joon YJ   Xiang Yufei Y   Cohen Tomer T   Belford Anna K AK   Huet Alexis A   Conway James F JF   Sun Ji J   Taylor Derek J DJ   Schneidman-Duhovny Dina D   Zhang Cheng C   Huang Wei W   Shi Yi Y  

Nature communications 20210803 1

Interventions against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are urgently needed. Stable and potent nanobodies (Nbs) that target the receptor binding domain (RBD) of SARS-CoV-2 spike are promising therapeutics. However, it is unknown if Nbs broadly neutralize circulating variants. We found that RBD Nbs are highly resistant to variants of concern (VOCs). High-resolution cryoelectron microscopy determination of eight Nb-bound structures reveals multiple potent neu  ...[more]

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